

Stata 16.0 was used to carry out the Meta-analysis. Outcome indicators included nerve conduction velocity, clinical efficiency, pain score, TCM syndrome score, and adverse events. Methods: We searched databases for randomized controlled trials (RCTs) of CHM in the treatment of PDN.

Objective: The objective of this systematic review and meta-analysis is to assess the effectiveness and security of Chinese herbal medicine (CHM) in the therapy of painful diabetic neuropathy (PDN). 4Department of Traditional Chinese Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.3Department of Oncology, Henan Provincial University of Traditional Chinese Medicine, Zhengzhou, China.

2Laboratory of Basic Medical Sciences, Qilu Hospital of Shandong University, Jinan, China.1First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.Min Song 1,2, Baogeng Huai 1, Zhenpeng Shi 1, Wenyi Li 1, Yutan Xi 3, Zhenguo Liu 1, Jihang Zhang 1, Junyu Zhou 1, Yun Qiao 4 and Deshan Liu 4*
